Transplant Rejection and the Placenta

The placenta has two major functions: nutrient exchange and protection of the foetus.

Inflammatory responses can develop at the maternal-foetal interface of the placenta. Loss of integrity at that interface may result in foetal antigens being presented to the maternal immune system. Additionally, ischaemic processes can release mediators that activate the maternal immune system.

These mechanisms may lead to adverse pregnancy outcomes and, in the worst‑case scenario, protect the mother by prematurely terminating the pregnancy.

We monitor for these events, and provide tailored support during pregnancy for impacted patients.